Neutrophil-7 and CD8 TE cells co-regulate the development of CML. (IMAGE)

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Neutrophil-7 and CD8 TE cells co-regulate the development of CML.

Caption

(A) The scatter plots showing the correlation between CD8 TE cells and the proportion of neutrophils. (B) The UMAP plot showing the clustering of neutrophils in CML and healthy samples. (C) Pseudotime trajectory of neutrophils in all samples by Monocle2. (D) The heatmap showing the normalized expression of top five transcription factor regulons in each neutrophil cluster predicted by pySCENIC. (E) The bubble plot showing the biological function enrichment of differential genes between neutrophil-7 in all samples. (F) The heatmap showing the difference of cell-cell communication between CD8 TE cells and neutrophil-7 in CML and control samples. Stars indicate significantly different ligand-receptor pairs. CML, chronic myeloid leukemia; TE, terminal effector.

Credit

Chenjian Zhuo, Xin Dong, Xueya Zhao, Weiru Wu, Hao Zhou, Jing Feng, Lingbo Liu, Mingqian Feng, Chunjiang He, Yu Hou

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