Composition and functional variation of T cells in CML. (IMAGE)
Caption
(A) Overview of this study. (B) The UMAP diagram showing the distribution of CD4, CD8, DNT, gdT, and MAIT in the samples. (C) The pie chart showing the ratio of T cells in CML and healthy samples. (D) The boxplot showing the cytotoxicity scores of CD8 T cells between CML and healthy samples. (E) The dot plot showing the expression of immunosuppression genes in CD8 T cells between CML and healthy samples. The size of the circle indicates the ratio of cells expressing these genes. (F) The heat map showing the differentially expressed genes of CD8 T cells between CML and healthy controls. (G) The bubble plot showing the biological functions of differentially expressed genes in CD8 T cells. CML, chronic myeloid leukemia; DNT, double negative T cells; gdT, γ-δ T cells; MAIT, mucosal-associated invariant T cells.
Credit
Chenjian Zhuo, Xin Dong, Xueya Zhao, Weiru Wu, Hao Zhou, Jing Feng, Lingbo Liu, Mingqian Feng, Chunjiang He, Yu Hou
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CC BY-NC-ND