The male susceptibility to cystinuria is independent of Slc7a13. (IMAGE)
Caption
The published single-cell RNA sequencing data representing the expression levels of Slc3a1 and Slc7a13 in mouse kidneys. The highlighted numbers are as below: 3-segment 1 of the proximal tubule (female), 4-segment 1 of the proximal tubule (male), 5-segment 2 of the proximal tubule (female), 6-segment 2 of the proximal tubule (male), 7-segment 3 of the proximal tubule (female), 8-segment 3 of the proximal tubule (male). The annotation of other numbers shown here can be found at https://cello.shinyapps.io/kidneycellexplorer/. (B) Relative mRNA levels of Slc7a9, Slc7a13, and Slc3a1 in the WT mouse kidneys. (C) Schematic diagram of the Slc7a13 and Slc3a1 double knockout (DKO) models. (D) Bladder stones in 20-week-old DKO mice from both sexes. (E) Relative mRNA levels of fibrosis and inflammatory genes (Col3a1, Vimentin, Fibronectin, IL-1β, and TNF-α) in the kidneys of DKO and WT mice from both sexes. (F) Representative images (left) of hematoxylin/eosin- and Sirius red-stained kidney sections of DKO and WT mice from both sexes and their quantification (right). Scale bar, 100 μm. All data are represented as mean ± standard error of the mean. p values were calculated by t-test or one-way ANOVA with the post hoc Tukey test. ∗∗∗∗p < 0.0001, ∗∗∗p < 0.001, ∗∗p < 0.01, ∗p < 0.05.
Credit
Genes & Diseases
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