Solid tumors resist CAR cell therapy through antigen heterogeneity, poor infiltration, and an immunosuppressive microenvironment. A new review argues that oncolytic viruses and CAR cells should be co-designed as an integrated, self-amplifying therapeutic system rather than simply combined. The authors describe how oncolytic viruses can install new targets, remodel the tumor microenvironment, and deliver local immune support, outlining engineering strategies, translational challenges, and future directions for next-generation solid tumor immunotherapy.

The grant will support research into a newly identified population of myelin-producing glial cells that cross the boundary between the brain and spinal cord and peripheral nerves. Using zebrafish, researchers will investigate how these cells form myelin and whether myelin-producing cells can function beyond the region where they normally reside. The study could reveal new mechanisms of nerve repair and inform future approaches to treating neurological disorders involving myelin loss, including multiple sclerosis.

Engineers can precisely control thread length and add segments with positive and negative electrical charges. This arrangement determines how the material interacts with living cells. In cell culture studies, the dynamic structures enhanced the growth and maturation of neurons, increased synapse formation and dramatically boosted neuronal activity.