Rutgers scientists have identified natural repellents against an invasive blueberry pest, a scientific breakthrough that was accidentally discovered when fruit flies invaded their laboratory.

The accident, more than a decade in the making, could one day transform how commercial crops are protected.

“As a kid, this is what I thought science was – you stumble on something and go, ‘Eureka!’” said Beth Ferguson, a postdoctoral researcher at the Rutgers Philip E. Marucci Center for Blueberry and Cranberry Research, and lead author of the study, published in the journal Applied and Environmental Microbiology. “Of course, that doesn’t happen most of the time, which is why I call this a very happy accident.”

Solid tumors resist CAR cell therapy through antigen heterogeneity, poor infiltration, and an immunosuppressive microenvironment. A new review argues that oncolytic viruses and CAR cells should be co-designed as an integrated, self-amplifying therapeutic system rather than simply combined. The authors describe how oncolytic viruses can install new targets, remodel the tumor microenvironment, and deliver local immune support, outlining engineering strategies, translational challenges, and future directions for next-generation solid tumor immunotherapy.

The grant will support research into a newly identified population of myelin-producing glial cells that cross the boundary between the brain and spinal cord and peripheral nerves. Using zebrafish, researchers will investigate how these cells form myelin and whether myelin-producing cells can function beyond the region where they normally reside. The study could reveal new mechanisms of nerve repair and inform future approaches to treating neurological disorders involving myelin loss, including multiple sclerosis.