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Latest news releases from NIH-funded organizations

Funded Research News

Updates every hour. Last Updated: 31-Oct-2025 09:11 ET (31-Oct-2025 13:11 GMT/UTC)

Children’s Hospital of Philadelphia researchers observe significant reduction in diagnosis of food allergies following expert guidelines encouraging early peanut exposure

Children's Hospital of Philadelphia
Peer-Reviewed Publication

Peanuts represent one of the most common causes of immunoglobulin E (IgE)-mediated, or anaphylactic, food allergies in children, yet a landmark study found that early introduction of peanut to infants may lower their risk of developing this allergy. Now, a new study has shown that the rates of diagnosis of peanut and other IgE-mediated food allergies have declined since the adoption of guidelines encouraging early introduction practices.

Journal: PEDIATRICS
Funder: NIH/National Institutes of Health, Hartwell Foundation, American Academy of Allergy Asthma and Immunology, American Partnership for Eosinophilic Disorders, Children's Hospital of Philadelphia, American Academy of Pediatrics, U.S. Department of Health and Human Services, The Food Allergy Fund

Treating liver disease with microscopic nanoparticles

Texas A&M University
Peer-Reviewed Publication

Texas A&M researcher Dr. Jyothi Menon and her collaborators have developed an innovative therapy that may halt inflammation and fibrosis in alcohol-related liver disease, offering hope for millions worldwide.

Journal: Biomaterials
Funder: NIH/National Institutes of Health, NIH/National Institutes of Health

Tumor-on-a-chip offers insight into cancer-fighting cells in immunotherapy

University of Pennsylvania
Peer-Reviewed Publication

The “tumor-on-a-chip” recreates the body’s tumor environment in miniature, complete with blood vessels and immune cells, so researchers can “see” what helps or hinders engineered immune cells inside solid tumors.

Adding vildagliptin, a drug currently used to treat type 2 diabetes, to the chip, allows many more CAR T cells to break through the protective tumor microenvironment and attack the tumor.

These chips could help accelerate the development of more efficacious and safer immunotherapies for cancer patients while reducing the need for the use of other preclinical models.

Journal: Nature Biotechnology
Funder: Cancer Research Institute, NIH/National Institutes of Health, U.S. National Science Foundation, Ministry of Trade, Industry and Energy of the Republic of Korea, National Research Foundation of Korea, Paul Allen Foundation, Ludwig Cancer Research, University of Pennsylvania

Research Spotlight: Surprising gene mutation in brain’s immune cells linked to increased Alzheimer’s risk

Mass General Brigham
Peer-Reviewed Publication

The study focused on one such mutation in the microglial gene TREM2, an essential switch that activates microglia to clean up toxic amyloid plaques (abnormal protein deposits) that build up between nerve cells in the brain. This mutation, called T96K, is a “gain-of-function” mutation in TREM2, meaning it increases TREM2 activation and allows the gene to remain super active.

Journal: Neuron
Funder: NIH/National Institutes of Health, NIH/National Institute of Diabetes and Digestive and Kidney Diseases, NIH/National Institute on Aging, Cure Alzheimer's Fund, Coins for Alzheimer's Research Trust, Freedom Together Foundation, BrightFocus Foundation

Craters on surface of melanoma cells found to serve as sites for tumor killing

Boston Children's Hospital
Peer-Reviewed Publication

Like the surface of the moon, new research published today in Cell finds the existence of craters on the surface of melanoma cells that serve as immune hubs, becoming major sites for tumor killing. These craters could serve as good markers for immunotherapy success.

Journal: Cell
Funder: Melanoma Research Alliance, NIH/National Cancer Institute

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