‘Chronic lung-transplant rejection has been a black box.’ New study gives answers, drug targets.
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Updates every hour. Last Updated: 30-Oct-2025 08:11 ET (30-Oct-2025 12:11 GMT/UTC)
More than 50% of lung-transplant recipients experience a rejection of their new lung within five years of receiving it, yet the reason why this is such a prevalent complication has remained a medical mystery.
Now, a new Northwestern Medicine study has found that, following transplant and in chronic disease states, abnormal cells emerge and “conversations” between them drives the development of lung damage and transplant rejection.
These findings not only help answer why rejection occurs, but they also have spurred immediate exploration of new drugs to treat transplant rejection and other lung-scarring diseases.
When harmful bacteria that cause food poisoning, such as E. coli, invade through the digestive tract, gut cells usually fight back by pushing infected cells out of the body to stop the infection from spreading.
In a new study published today in Nature, scientists from Genentech, a member of the Roche Group, in collaboration with researchers from Oregon Health & Science University, discovered that a dangerous strain of E. coli — known for causing bloody diarrhea — can block gut this defense, allowing the bacteria to spread more easily.
Ants have evolved an acute sense of smell, which requires each sensory neuron to choose one scent receptor out of hundreds. In a new study published in Nature, researchers at New York University have discovered what ants use to solve this biological puzzle: a self-regulating system in which choosing one gene physically silences all its neighbors.