The E3 ubiquitin ligase MIEL1 promotes thermo-responsive growth by blocking auto-ubiquitination and self-degradation of XBAT31
Peer-Reviewed Publication
Updates every hour. Last Updated: 9-May-2026 16:16 ET (9-May-2026 20:16 GMT/UTC)
Global warming has severe impacts on plant growth and development, and XBAT31 controls the protein level of the thermosensor ELF3 to promote hypocotyl growth under warm temperature conditions. In the current study, researchers unveil MIEL1 as a stabilizer of XBAT31, suppressing its auto-ubiquitination independent of MIEL1’s canonical RING-domain activity, and act cooperatively to modulate hypocotyl elongation in response to warm temperature. This hierarchical interaction between two E3 ligases expands the paradigm of ubiquitin-mediated signaling in environmental adaptation.
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