Why cancer immunotherapy fails: Ohio State researchers link it to protein quality control collapse
Peer-Reviewed Publication
Updates every hour. Last Updated: 14-Dec-2025 21:11 ET (15-Dec-2025 02:11 GMT/UTC)
In what experts are calling a paradigm-shifting landmark study, scientists from The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) report key findings about the underlying mechanisms of immune system stress response to protein misfolding, launching a new approach to cancer immunotherapy treatment targeting the protein production cycle.
In a major blow to public health, the Superior Court of California has ruled that the State of California may ignore the dangers of processed meat, a product that the World Health Organization has classified as “‘carcinogenic to humans’ (Group 1) on the basis of sufficient evidence for colorectal cancer.”
Cancer center researchers developed a safer, more targeted gene therapy to kill cancer cells linked to a common herpesvirus — potentially transforming treatment.
A Multi-Party Team represented by Carnegie Mellon University researchers and private industry partners has secured an award of up to $26.7 million from the Advanced Research Projects Agency for Health (ARPA-H) Platform Optimizing SynBio for Early Intervention and Detection in Oncology (POSEIDON) program to usher in a new era of proactive cancer screening, offering an at-home solution to detect over 30 Stage 1 solid tumor cancers from a simple urine sample.
A diet rich in cysteine has rejuvenating effects in the small intestine, according to a new study. The amino acid can turn on an immune signaling pathway that helps stem cells regrow new intestinal tissue, which could help heal injuries from radiation or chemotherapy.