Evidence-based strategies improve colonoscopy bowel preparation quality, performance, and patient experience
Reports and Proceedings
Updates every hour. Last Updated: 12-May-2025 16:09 ET (12-May-2025 20:09 GMT/UTC)
People with intellectual disabilities (ID) are significantly less likely to participate in population-based cancer screening than the general population, according to researchers from Radboudumc and academic collaborative Intellectual Disability and Health - Sterker op eigen benen in The Lancet Public Health.
A new review article published in Genes & Diseases explores the intricate relationship between non-coding RNAs and oxidative stress in cancer progression shedding new light on the mechanisms that drive tumor development. As cancer incidence continues to rise, particularly among younger populations, researchers are uncovering key molecular interactions that could transform the landscape of targeted therapies.
Poly adenosine diphosphate-ribose polymerase (PARP) inhibitors, a class of targeted anticancer therapies, prevent genetic repair mechanisms in cancer cells by competitively binding to the active site of PARP and limiting its activity. A new review study by researchers from Sichuan University, China, outlines the molecular mechanisms of PARP inhibitors and the potential for combination therapies comprising PARP inhibitors and other anticancer drugs to improve treatment outcomes against various cancers while limiting the adverse effects.
A review in Brain Medicine unveils the potential of targeted alpha particle therapy (TAT) as an innovative and exciting breakthrough for neuroendocrine tumours (NETs). Unlike traditional beta-particle treatments, TAT delivers high-energy alpha particles to devastate tumour DNA with precision, offering hope for patients with resistant cancers. Published on 4 March 2025, this study highlights preclinical successes and clinical breakthroughs, positioning TAT as a game-changer in oncology amidst ongoing challenges.
The National Institutes of Health (NIH) serves as an important source of funding for clinical trials in children, especially for diseases, such as cancer, that are not as highly prioritized in industry-sponsored clinical trials, according to a recent study published in The Journal of Pediatrics. The study evaluated how the number of pediatric clinical trials, as an indicator for industry and NIH research priorities, compared with the burden of childhood disease in the United States.