Peritoneal metastases, a late-stage cancer that has spread from the abdominal organs to the abdominal lining, is fuelled by surrounding fluid called ascites, but its molecular makeup has never been comprehensively mapped until now.

A study led by the National Cancer Centre Singapore (NCCS) analysed one of the largest ascites datasets in the world; 397 samples across 21 cancer types and identified two proteins, PAI-1 and S100A10, as key drivers of tumour growth.

Building on this, the team developed a novel nanobody, E8, targeting the protein PAI-1, and demonstrated the nanobody can suppress tumour growth in lab, animal, and human tissue models with minimal toxicity.

A new biologics programme, the Melyorax Initiative, will advance E8 and other novel treatment strategies towards clinical trials for patients who currently have limited treatment options.

While doctors fight to save the lives of cancer patients in intensive care, family members, partners and friends are often left carrying a heavy burden of their own, with research revealing widespread anxiety, depression, exhaustion and declining wellbeing among those supporting a loved one through a critical illness.

Staying active before surgery may do more than strengthen the body for recovery — it may protect the brain. Regular physical activity at least seven times a week before cancer surgery was linked to a lower risk of developing postoperative delirium, according to research presented at the ANESTHESIOLOGY^® 2026 annual meeting.

A next-generation total-body PET/CT scanner can produce diagnostic-quality images in as little as one minute of scanning, according to research presented today at the 39th Annual Congress of the European Association of Nuclear Medicine (EANM’26). Even its fastest images were rated more highly on average than those from a standard PET/CT scanner.