Hepatocellular carcinoma (HCC) is one of the most fatal malignancies. Epigenetic mechanisms have revealed that noncoding RNAs, such as microRNAs (miRNAs) and circular RNAs (circRNAs), are involved in HCC progression. This study aimed to construct a circRNA-miRNA-mRNA network in HCC and validate one axis within the network.

Mesothelioma is an aggressive tumor with a poor prognosis. Histological diagnosis of mesothelioma using limited tissue samples can be challenging. Carbonic anhydrase IX (CAIX) is a transmembrane protein that is overexpressed in a variety of solid tumors. This study aimed to investigate the clinical utility of CAIX expression in the differential diagnosis of pleural mesothelioma from non-small cell lung carcinoma (NSCLC).

A comprehensive new 10-year study led by researchers at Arizona State University examined more than 16,000 necropsy records from 292 vertebrate species, revealing significant differences in the prevalence of cancer. The findings offer new insights into cancer evolution while challenging Peto’s paradox — a key concept in evolutionary biology.

An international team led by researchers at the University of Toronto and the Broad Institute of MIT and Harvard has assembled the first large-scale, publicly available map to show the impact of mutations on where proteins end up in the cell.

After seven months of living and working onboard the International Space Station (ISSInternational Space Station), astronauts of NASA’s eighth rotational SpaceX crew mission (Crew-8) splashed down safely off the coast of Florida. The mission, which is part of NASA’s Commercial Crew Program, included NASANational Aeronautics and Space Administration astronauts Matthew Dominick, Michael Barratt, and Jeanette Epps, as well as Roscosmos cosmonaut Alexander Grebenkin. During their mission on station, the three NASA astronauts supported dozens of research investigations sponsored by the ISS National Laboratory®.

Researchers at Winship Cancer Institute of Emory University have identified a novel type of immune cell, called the stem-like CD4 T cell, that plays a pivotal role in anti-tumor immunity. The pre-clinical findings, published in Nature, highlight the potential to activate these cells to fight tumors more effectively, offering new hope for broader treatment success, particularly in patients with cancer that is unresponsive to current immunotherapies.