Emanuel Petricoin, III, Co-Director, Center for Applied Proteomics and Molecular Medicine (CAPMM), received funding for a breast cancer study.

University of Calgary study reveals new insights that could help in the diagnosis and treatment of invasive skin cancers, like Marjolin’s ulcer (MU), that grow on chronic burn wounds. The research team completed a cell-by-cell analysis to better understand how MU tumours grow. Using both single cell RNA sequencing and spatial transcriptomics provided precise mapping of gene expression and cellular interactions within tumor tissue sections. With that enhanced view the researchers discovered that a subset of the dermal fibroblasts residing within the tumor, appeared to have come from keratinocytes that typically comprise the outer layer of the skin called epidermis. Findings are published in the Journal of Investigative Dermatology. 

The prevalence and fatality rates of cutaneous malignant melanoma (CMM) have been rising, particularly among the elderly. This study analyzes CMM incidence trends in the United States elderly population from 1987 to 2016 to inform prevention and management strategies.

Washington, DC –  The 2024 National Foundation for Cancer Research (NFCR) Global Summit and Award Ceremonies for Cancer Research & Entrepreneurship, co-hosted with the AIM-HI Accelerator Fund, convened the world’s top experts across cancer research, biotech entrepreneurship, pharmaceuticals, investment, and patient advocacy. This prestigious event, held at the National Press Club, served as a unique forum for advancing groundbreaking science, fostering innovative collaborations, identifying critical unmet needs for patients, and driving forward breakthrough solutions. This event highlighted cutting-edge cancer research advancements, the emerging area of early detection and early intervention research, utilizing artificial intelligence (AI) in improving cancer diagnostics, drug development, and personalized treatment strategies—revolutionizing the future of cancer care.

Tumor molecular analysis using next-generation sequencing (NGS) is the standard of care for guiding lung cancer treatment. Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive technique used to sample mediastinal lymph nodes for diagnosing and staging lung cancer. This study aimed to determine if EBUS-TBNA provided adequate tissue samples for NGS.

Infection with HPV16, a high-risk human papillomavirus (HPV), can cause cervical cancer in humans. These infections carry a high risk of morbidity and mortality globally in females. This study aimed to conduct an in vivo comparison of Poly (D,L-lactic-co-glycolide) (PLGA)-encapsulated peptide mixture nanoparticles and PLGA microspheres as delivery systems for vaccines.