A new study in mice hints at the potential to use tiny particles made with RNA molecules to deliver chemotherapy drugs and other therapies directly to tumors, killing cancer cells without generating an immune response or toxicity-related side effects.

Researchers at Baylor College of Medicine have uncovered a strategy that triple negative breast cancer (TNBC) cells use to boost their ability to metastasize, or spread to other organs. Metastasis is the leading cause of cancer-related deaths and scientists are investigating ways to prevent it. These findings highlight new possibilities for developing clinical interventions to treat metastatic TNBC patients for whom there are no specific therapies.

A study coordinated by the Institut de Neurociències of the Universitat Autònoma de Barcelona proposes a new treatment for glioblastoma, the most aggressive brain tumor. The approach involves patches tested in cell cultures and in excised pig brains that induce a high level of cellular oxidation in a local and controlled manner, thereby minimizing potential systemic side effects.

Cancer research is undergoing a profound transformation. Advances in molecular and cellular biology, genomics, immunology, engineering, and computational science have reshaped our understanding of cancer as a complex, multiscale disease. Yet the gap between biological discovery and durable clinical benefit remains a central challenge. Addressing this gap increasingly requires integration across disciplines, technologies, and conceptual frameworks. Advanced Cancer Research is an international, peer-reviewed, open-access journal publishing original cancer research spanning basic, translational, and clinical investigation. The journal prioritizes studies that provide mechanistic depth, introduce conceptual or technological innovation, or offer system-level insight into cancer biology and therapy, with particular emphasis on work that bridges disciplinary boundaries and advances translational relevance.