Whole brain radiotherapy (WBRT) saves lives by treating cancer that has spread to the brain, but it also causes long-standing brain damage. Many patients develop memory problems, thinking difficulties, and depression after WBRT. There are currently no medicines that adequately prevent these problems of WBRT. The research team discovered that an experimental neuroprotective drug, P7C3-A20, could protect the brain from these harmful side effects of WBRT in animal models, without impairing the ability of radiation to kill tumor cells. If these findings translate to humans, adding a drug like P7C3-A20 to WBRT could safely and effectively preserve cognition and mood after lifesaving WBRT.

Study to be presented at this year's ESGO 2026 , demonstrates significant overall survival benefit with Elenagen plus Gemcitabine in one of the deadliest gynecologic malignancies

The application of food as a medical intervention is founded on decades of evidence demonstrating that various plant-forward dietary patterns are associated with reduced risk of cardiovascular disease, dementia, type 2 diabetes and cancer, and all-cause mortality, while greater consumption of ultra-processed foods is associated with higher risks of a variety of adverse health outcomes, such as cardiometabolic disease, common mental disorders, and mortality outcomes. 

The BBVA Foundation Frontiers of Knowledge Award in Biology and Biomedicine has gone in this eighteenth edition to Carl June (University of Pennsylvania) and Michel Sadelain (Columbia University) for revolutionizing the treatment of cancer by means of CAR-T cell immunotherapy. The two laureates pioneered this innovative therapeutic strategy whereby T cells are extracted from the patient’s own immune system, grown in the lab and genetically engineered so they recognize and selectively destroy cancer cells on being infused back into the body, leading to remission of the disease.

City of Hope Research Spotlight offers a glimpse into groundbreaking scientific and clinical discoveries advancing lifesaving cures for patients with cancer, diabetes and other chronic, life-threatening diseases. Each spotlight features research-related news, such as recognitions, collaborations and the latest research defining the future of medical treatment. This roundup of six studies highlights new insights into cancer treatment, immune balance and early disease detection.