Inhibiting transcriptional hub: a phase-separating RNA polymerase alpha subunit as a first-in-class agrochemical target against Xanthomonas
Peer-Reviewed Publication
Updates every hour. Last Updated: 22-Oct-2026 14:16 ET (22-Oct-2026 18:16 GMT/UTC)
Starting from syringic acid, a natural phenolic acid with favorable safety and biodegradability features, Prof. Runjiang Song's team at the State Key Laboratory of Green Pesticide, Guizhou University, designed a series of derivatives by combining the syringic acid scaffold with an allicin-inspired disulfide unit and a 1,3,4-oxadiazole moiety. Among 34 derivatives, compound C31 emerged as the most potent anti-Xoo molecule, with an EC50 of 0.86 μg/mL. In rice pot experiments, C31 achieved 59.37% control efficacy against bacterial leaf blight, outperforming syringic acid and the commercial reference thiodiazole copper in this study.
A research team led by Professors Jiafu Wang and Jue Qu has jointly developed an eye-tracking-driven, polarization-agile, and beam-programmable metasurface. This system integrates high-precision eye-tracking technology with advanced programmable metasurface design, enabling real-time 3D beam focusing and adaptive reconfiguration of polarization modes for wireless communication signals. This achievement was published in Research under the title "Eye-Tracking-Driven Programming Metasurface System for Adaptive Beam Focusing and Polarization-agile Communication".
A research paper by scientists at Central South University developed a bioinspired digital twin platform integrating variational representation learning with causal sequence modeling.
The research paper, published on Jun 16, 2026 in the journal Cyborg and Bionic Systems.
This study revealed the complete molecular mechanism by which P.g induced microglial ferroptosis through the NOX4/PPAR-α/PGC-1α pathway, thereby driving neuroinflammation and cognitive impairment, providing a molecular target and theoretical basis for drug repurposing targeting NOX4 to intervene in periodontitis-associated Alzheimer's disease.
To address this limitation, research teams led by Prof. Kai Zhang (University of Göttingen) and Prof. Rongxin Su (Tianjin University) have developed an integrated salt-assisted assembly (iSAA) that couples ion crosslinking with organic–inorganic co-assembly to construct nanofibril–crystal (NF-C) composite films exhibiting vivid, tunable interference colors. The work has been recently published in Research.