Professors Yubo Fan and Xufeng Niu’s team at Beihang University reports new progress in collagen fiber arrangement–mediated regulation of pathological calcification
Peer-Reviewed Publication
Updates every hour. Last Updated: 10-Oct-2025 15:11 ET (10-Oct-2025 19:11 GMT/UTC)
The research team led by Professors Yubo Fan and Xufeng Niu at Beihang University systematically investigated the changes in collagen fibers within atherosclerotic plaques by establishing an ApoE knockout mouse model fed with a high-fat diet, combined with histological staining, immunohistochemistry, and in vitro experiments. Their findings revealed a progressive decline in CFA orientation as AS advanced, with regions of randomization coinciding with inflammatory responses, smooth muscle cell (SMC) phenotype switching, osteogenic gene expression, and vascular calcification. These results highlight CFA as a valuable indicator for delineating lesion regions and assessing disease stages, thus providing theoretical support for early diagnosis and therapeutic intervention.
This work proposes a novel lower-limb motion capture system that, for the first time, combines a flexible pressure sensor array with a Transformer-based temporal regression model. The system enables accurate estimation of lower-limb joint positions using only insole-embedded sensors.
The research team found that the supplementation of n-3 fatty acids significantly enhances lactation performance even in non-inflammatory states, suggesting the existence of an unexplored direct regulatory mechanism.
A research paper by scientists at University of Southern Denmark presented a multimodal limbless crawling soft robot capable of navigating complex terrains using a combination of rectilinear motion and asymmetric steering gaits.
The research paper was published on Jun. 9, 2025 in the journal Cyborg and Bionic Systems.