The photoreaction cycle of the blue-light receptor protein BLUF domains involves forward and reverse proton-coupled electron transfer (PCET) reactions, yet a unified cross-species mechanism is lacking. By capturing the key proton relay intermediates, for the first time we resolved the photoreaction mechanism of the BLUF domain light state using a unified kinetic model.

Researchers discovered that an A216V mutation in the unrearranged PML allele confers resistance to arsenic trioxide in acute promyelocytic leukemia, revealing a hidden cause of relapse and underscoring the need for genetic screening to guide personalized treatment.

Scientists have conducted a study of the predatory behavior of sharks in deep-sea ecosystems. This research provides insights into the behavior and distribution range of Pacific sleeper sharks. The research is published in the journal Ocean-Land-Atmosphere Research on June 1, 2025.

A comprehensive review reveals that blocking natural killer cell checkpoints and employing precision strategies like gene editing and engineered cell therapies could significantly enhance cancer immunotherapy outcomes for solid tumors and blood cancers.