A hybrid lifestyle program and metabolic health in adults with obesity

About the Study: In this randomized clinical trial of 200 adults with obesity receiving care in Brazil’s public health care system, a hybrid-format lifestyle intervention did not improve the likelihood of achieving 5% or greater weight loss in the intention-to-treat analysis. However, secondary and per-protocol analyses suggested potential cardiometabolic benefits among adherent participants, warranting further investigation.

Corresponding Author: Graziele Souza de Menezes Amorim Coelho, MS, Rua Dr. Enéas de Carvalho Aguiar, 155 - 5° andar, Bloco 4B - Sala 11A, São Paulo, SP, 05403-000, Brasil (graziele.amc@gmail.com).

10.1001/jamanetworkopen.2026.26884

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