About The Study: The findings of this study support standard-dose amoxicillin as a preferred empiric choice for adults younger than 65 years with uncomplicated acute sinusitis for whom an antibiotic is indicated.
Corresponding Author: To contact the corresponding author, Timothy J. Savage, MD, MPH, MSc, email tsavage@mgb.org.
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(doi:10.1001/jama.2025.26902)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Media advisory: This study is being presented at the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Global 2026 congress.
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Journal
JAMA