About The Study: Compared with usual care, use of the PETRUSHKA tool increased the number of patients still taking their antidepressant at 8 weeks and improved depressive and anxiety symptoms at 24 weeks. However, lack of a double-blind design and the large amount of missing data limit the validity of these results. The PETRUSHKA tool is a web-based clinical decision-support system combining clinical and demographic predictors with patient preferences to personalize antidepressant treatment.
Corresponding Author: To contact the corresponding author, Andrea Cipriani, MD, PhD, email andrea.cipriani@psych.ox.ac.uk.
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(doi:10.1001/jama.2026.1327)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Journal
JAMA