About The Study: This pilot randomized clinical trial established feasibility, confirmed safety and tolerability, and generated effect size estimates for future trials of low-dose lithium in mild cognitive impairment. None of the coprimary outcomes met the prespecified significance threshold.
Corresponding Author: To contact the corresponding author, Ariel G. Gildengers, MD, email ariel.gildengers@pitt.edu.
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(doi:10.1001/jamaneurol.2026.0072)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Journal
JAMA Neurology