image: Researchers have studied the gut microbiota diversity in normal-weight and underweight Japanese women, with significant differences in gut microbial diversity despite the same diet.
Credit: Dr. Katsumi Iizuka from Fujita Health University, Japan Image source link: https://www.mdpi.com/2072-6643/17/20/3265#
Low body weight in young women has been linked to a range of health concerns, including disrupted menstrual cycles, infertility, weakened immune function, and a long-term decline in bone density. Japan has seen a rising trend in the proportion of underweight women between the ages of 20 and 39, with little to no change over the past two decades. The persistence of this trend raises concerns over the long-term health implications, especially as lean body weight has been correlated with changing dietary habits, diseases like anorexia nervosa, and even imbalances in gut microbiota. While previous research has reported lower alpha gut microbiota diversity in the underweight and overweight categories compared to those with normal weight, the differences in gut microbiota diversity in young, underweight Japanese women remain unclear.
To explore this further, a team of researchers from Japan, led by Dr. Katsumi Iizuka, a Professor at the Department of Clinical Nutrition, Fujita Health University, Japan, and Dr. Hiroaki Masuyama, Symbiosis Solutions Inc., set out to investigate the link between body type, dietary patterns and gut microbiota diversity in young, underweight Japanese women. They focused on understanding whether the gut microbiota diversity differed significantly between women who were underweight and those with normal body mass index (BMI). Their research was published in Volume 17, Issue 20 of the journal Nutrients on October 17, 2025. Prof. Iizuka says, “The differences in the diversity of the gut microbiota of young Japanese women by body weight have not been investigated. If differences in the gut microbiota between thin young women and women of normal weight become clear, I believe that improving eating habits could lead to improvements in the gut microbiota and consequently, body weight.”
The study observed and compared 40 underweight women with 40 age-matched women, between 20 and 39. The underweight group included women who were referred to the Nutrition Clinic at Fujita Health University with a BMI less than 17.5 at their first consultation, while the control group was composed of women with normal BMI (18.5 ≤ BMI < 25) and were selected from a database by Symbiosis Solutions Co., Ltd. (Tokyo, Japan). Stool samples were collected using standardized kits, while food frequency questionnaires were used to assess dietary patterns.
Interestingly, the researchers found no significant differences in dietary patterns between the two groups. However, an analysis of the gut microbiota showed that underweight women had a significantly lower microbiota diversity and an increased presence of species, such as Bacteroides, Bifidobacterium, and Erysipelatoclostridium, which are linked to inflammation. On the other hand, the normal-weight group had a healthier abundance of bacteria like Prevotella and Dorea. Prof. Iizuka mentions, “Among Japanese women aged 20–39, those in the underweight group showed a greater decrease in gut microbiota diversity compared to the normal-weight group, rather than differences in dietary patterns.” He adds, “Underweight women demonstrated reduced gut microbiota diversity and enrichment of taxa associated with inflammatory tendencies.”
These findings suggest that gut health is as important as caloric intake when it comes to addressing low body weight. Prof. Iizuka explains, “Not only the amount of energy or the ratio of protein, fat, carbohydrate, but actively consuming dietary fiber and fermented foods may lead to weight improvement in underweight individuals by causing changes in the gut microbiota.”
When asked about the long-term implications of the study, he said, “By combining the dietary survey data with gut microbiota analysis, it may become possible to evaluate not only the nutrients and energy contained in food, but also the quality of digestion and metabolism within the intestines after eating.”
With gut health gaining global attention, the findings of this study offer new insights into how the gut microbiota could aid in more personalized nutritional care for underweight Japanese women.
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Reference
DOI: 10.3390/nu17203265
About Fujita Health University
Fujita Health University (FHU) is a private medical university located in Aichi, Japan. Established in 1964, it houses one of the largest university hospitals in Japan. It's 900 member faculty provides diverse learning and research opportunities to medical students worldwide. Guided by its founding philosophy of "Our creativity for the people" Fujita Health University believes that it's students can shape the future through creativity and innovation. FHU has earned global recognition, ranking eighth among all universities and second among private universities in Japan in the 2020 Times Higher Education (THE) World University Rankings. The university ranked fourth worldwide in the 2024 THE University Impact Rankings for contributions to the "Good Health and Well-being" SDG (Sustainable Development Goals) of the United Nations (UN). In June 2021, the university made history as the first Japanese institution to host the THE Asia Universities Summit. In 2024, Fujita Health University was awarded the Forming Japan’s Peak Research Universities (J-PEAKS) Program by the Japanese government to establish an innovative academic drug discovery ecosystem and hub of a multi-university consortium for research and education.
Website: https://www.fujita-hu.ac.jp/en/index.html
About Professor Katsumi Iizuka from Fujita Health University
Dr. Katsumi Iizuka is a Professor in the Department of Clinical Nutrition, Fujita Health University, Japan. He earned his MD from the Graduate School of Medicine at The University of Osaka, specializing in internal medicine. As a leading expert in metabolic and clinical nutrition, his research focuses on obesity, diabetes mellitus, and lipid metabolism. With over 100 peer-reviewed publications, Dr. Iizuka has made significant contributions to the understanding of nutrient signaling pathways, energy balance, and metabolic regulation. His work is recognized both in Japan and internationally, and he continues to advance the field through his research.
Funding information
Funds from the university’s departmental research budget were used.
Journal
Nutrients
Method of Research
Observational study
Subject of Research
People
Article Title
Gut Microbiota α- and β-Diversity, but Not Dietary Patterns, Differ Between Underweight and Normal-Weight Japanese Women Aged 20–39 Years
Article Publication Date
17-Oct-2025
COI Statement
Regarding material and human support, the distribution data of intestinal microbiota was provided by Symbiosis Solutions Co., Ltd. Part of the statistical analysis was also conducted at Symbiosis Solutions Co., Ltd. The authors, Kana Okuma, Masako Yamada, and Hiroaki Masuyama, were employed by Symbiosis Solutions Inc. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. An application was submitted to the Fujita Health University Conflict of Interest Committee, and conflict of interest management was conducted.