The Gabriella Miller Kids First Pediatric Research Program (Kids First) has released its 36th study and introduced significant new data updates to two existing studies, further advancing efforts to uncover the genetic foundations of childhood cancers and congenital conditions. This brings the total data files available at the Kids First Data Resource Center (Kids First DRC) to more than 110,000.
WHO: Kids First, a program from the National Institutes of Health (NIH)
WHAT: Announcing the latest data releases to the Kids First data ecosystem. Newly released and updated datasets are available publicly, including:
CONGENITAL CONDITIONS
Kids First: Whole Genome Sequencing Studies of Multiplex Nonsyndromic Cleft Lip/Palate Families (KF-MNC)
Apply via dbGaP: phs002626
Principal Investigator: Ariadne M. Letra, PhD, University of Pittsburgh
This new study, Kids First’s 36th, explores nonsyndromic cleft lip/palate, a condition that accounts for 65% of all congenital anomalies. Short-read whole-genome sequencing (WGS) data from 828 participants in 168 multigenerational families are now available.
Kids First: Congenital Diaphragmatic Hernia (KF-CDH)
Apply via dbGaP: phs001110
Principal Investigator: Wendy Chung, MD, PhD, Columbia University Medical Center
This longstanding study received a major data update: over 1,600 new participants, 2,100 samples, and additional modalities including RNA-Seq and PacBio long-read sequencing. Congenital diaphragmatic hernia is one of the most common and lethal congenital anomalies, affecting 1 in 3,000 live births.
CHILDHOOD CANCERS
Kids First: T-cell Acute Lymphoblastic Leukemia (KF-TALL)
Apply via dbGaP: phs002276
Principal Investigator: David T. Teachey, MD, Children’s Hospital of Philadelphia
A small update adds 2 new RNA-Seq samples. This study seeks to improve risk stratification and identify genetic drivers of relapse and treatment toxicity in pediatric T-ALL.
WHEN: All datasets are available now.
WHERE: Access and explore these new data through the Kids First Data Resource Portal. Instructions for requesting access to controlled data are available in the Kids First Help Center.
WHY: By releasing high-quality genomic data from children and families affected by pediatric cancers and congenital conditions, Kids First empowers researchers everywhere to uncover new diagnostic markers, therapeutic targets, and disease risk factors. This publicly available resource promotes data sharing and collaborative discovery that could lead to life-changing treatments for children.
About the Gabriella Miller Kids First Data Resource Center (Kids First DRC)
Kids First DRC, part of the NIH Common Fund Gabriella Miller Kids First Pediatric Research Program, is a centralized, open-access, cloud-based platform that enables pediatric researchers to study the genetic links between childhood cancers and congenital conditions. It supports a global community of scientists, clinicians, and patient families working together to accelerate cures for children. Learn more at kidsfirstdrc.org.
Press Contact
Whitney Rife
rifew@chop.edu
Method of Research
Data/statistical analysis
Subject of Research
Not applicable