image: 16th International Conference on Skin Ageing & Challenges 2025
November 11-12 in Valencia, Spain.
Credit: Skin Ageing & Challenges 2025
The 16th International Congress on Skin Ageing & Challenges will bring together a global panel of scientists, clinicians, and industry innovators to explore the latest breakthroughs in skin ageing research, from molecular mechanisms to real-world applications in prevention, rejuvenation, and smart skincare.
Hosted in Valencia, Spain, the meeting will address the biological complexity of skin ageing, which is shaped by both intrinsic factors (cellular senescence, genetic programming, protein homeostasis) and extrinsic factors (UV exposure, pollution, microbiome shifts). Understanding and targeting these processes is crucial not only for skin health, but also for broader healthy ageing strategies.
The Complexity of Skin Ageing, and the Strategy Gap
Skin ageing is far from a simple, linear process. It involves an intricate network of molecular damage, cellular stress responses, immune modulation, and environmental triggers that evolve over decades. This multifactorial nature makes it extremely challenging to design interventions that are both scientifically robust and clinically effective.
Current approaches often address isolated mechanisms, but the emerging consensus is that multi-target, integrated strategies will be required, combining senescence modulation, microbiome restoration, and metabolic and epigenetic reprogramming. Skin Ageing & Challenges 2025 will serve as a platform to align basic science with translational innovation, accelerating the path toward such comprehensive solutions.
Pioneering Scientific Program
The congress will open with a keynote by Prof. Vladimir A. Botchkarev (Boston University School of Medicine, USA) on the epigenetic regulation of skin ageing-associated genes in short-lived and long-lived mammals — a comparative approach that could identify novel protective pathways.
Key themes across the two-day event include:
- Cellular Senescence & Interventions:
Cutting-edge senolytic and senomorphic strategies, NK cell–based rejuvenation, and targeting mTORC1–lysosomal pathways (Cláudia Cavadas, Karin Scharffetter-Kochanek, Bernadette Carroll). - Epigenetic & Circadian Control:
How circadian proteomics and comparative epigenomics can detect early structural and functional changes (Thomas Mortimer, Manuel Collado, Ramon Martinez Mañez). - Skin-Microbiome-Immune Dialogue:
Innovative approaches to restoring microbial balance and environmental regulation of skin homeostasis (Mathew Hardman, Andrzej Słominski). - Damage, Repair & Proteostasis:
Novel strategies to counter inflammaging and maintain protein quality (Christopher Griffiths, Sebastian Iben).
From Lab to Market:
Translation of nanotechnology-enabled senescent cell targeting, biomaterials, and polyphenol-based actives into next-generation skincare solutions.
Call for Abstracts & Innovation Pitches
Researchers and companies are invited to submit abstracts for short oral presentations and innovation pitches. Dedicated sessions will spotlight polyphenol innovations, smart biomaterials, and other emerging technologies ready for clinical and commercial translation.
Impact Beyond the Skin
“The skin is both a barrier and a biological sensor,” says Jean Krutmann, President of Skin Ageing & Challenges 2025. “By understanding its ageing processes, we not only improve dermatological health but also gain insights into systemic ageing and potential whole-body rejuvenation strategies.”
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📅 Event: Skin Ageing & Challenges 2025
📍 Location: Valencia, Spain
🗓 Dates: November 11–12, 2025
🌐 Website: www.skin-challenges.com
Press Contact:
Skin Ageing & Challenges Press Office