About The Study: In this randomized clinical trial of antihypertensive chronotherapy, bedtime dosing provided better control of nocturnal blood pressure and improved the circadian rhythm, without reducing the efficacy on mean daytime or 24-hour blood pressure, or increasing the risk of nocturnal hypotension. These findings support the potential advantages of bedtime administration and offer new evidence to guide future research on antihypertensive chronotherapy.
Corresponding Author: To contact the corresponding author, Xiaoping Chen, MD, email xiaopingchen15@126.com.
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(doi:10.1001/jamanetworkopen.2025.19354)
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