About The Study: In patients with acute large vessel occlusion presenting between 4.5 and 24 hours of symptom onset, intra-arterial tenecteplase after successful thrombectomy had a greater likelihood of excellent neurological outcome at 90 days without increasing the risk of symptomatic intracranial hemorrhage or mortality. However, because none of the secondary efficacy analyses supported the primary finding, further trials are needed to confirm the results.
Corresponding Authors: To contact the corresponding authors, email Xiaochuan Huo, PhD, (huoxiaochuan@126.com) and Bernard Yan, MD, (bernard.yan@mh.org.au).
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(doi:10.1001/jama.2025.10800)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Media advisory: This study is being presented at the 11th Annual Conference of the Chinese Stroke Association & Tiantan International Stroke Conference 2025.
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Journal
JAMA