Love is blind for male fruit flies who will choose sex over safety

Male fruit flies will become oblivious to physical danger as they become more engaged in courtship and sex, new research shows.

Researchers at the University of Birmingham have shown that pursuit of a coveted reward – in this case a female fly – will cause a male fruit fly to ignore threats such as predation.

In the study, published today (28 Aug) in Nature, the team was able to show for the first time the neural networks in the fly’s brain that direct this decision-making process, revealing the neurotransmitter dopamine has a leading role to play.

Lead researcher Dr Carolina Rezaval said: “Every day we make decisions that require us to balance opportunities and risk – but we know little about what is happening in our brains as we make these choices.

“By studying the neural pathways that are activated in the brains of fruit flies we can find out more about these processes. As the fly pursues his courtship and is close to mating, we can clearly see that when a threat is introduced, he simply does not see it.”

In their experiment, the researchers used two-photon microscopy to look at which neurons in the fly’s brain were activated during the courtship. The team introduced an artificial threat using light and shadow to simulate the effect of a predator flying nearby.

Dr Laurie Cazale-Debat, a leading researcher in Rezaval’s group at the University of Birmingham, said: “During earlier stages of courtship, we found the presence of threat triggered certain visual neurons in the brain that interfere with neurons governed by serotonin. This prompts flies to abandon their courtship and escape the threat.

“As the courtship advances, however, the increase in dopamine blocks key sensory pathways, reducing the ability of the fly to respond to threat and causing it to focus on mating.”

Dr Rezaval explains: “The animal must decide about what is most important. Dopamine is key to this decision-making process, but the levels of dopamine are closely related to the proximity of the goal – how likely is success?

“You can see this kind of motivation at play all the time among humans. Imagine you’re climbing a mountain and you’re close to the summit,” added Dr Lisa Scheunemann, a group leader from Freie Universität Berlin and key contributor to the study. “If the weather changes and conditions become dangerous you might disregard that threat because you are so close to your goal.”

Dr Rezaval concludes: ‘Our study shows that as courtship progresses, dopamine increases, acting as a sensory filter that blocks distractions and helps the animal focus on the task at hand when close to its goal. We are excited to explore if this is a general decision-making mechanism that is also present in mammals, including humans.”

This work was done in collaboration with Dr Lisa Scheunemann (Freie Universität Berlin), Dr David Owald’s group (Charité - Universitätsmedizin Berlin) and Dr Andrew Lin’s group (University of Sheffield). The research was supported by the Biotechnology and Biological Sciences Research Council, The Leverhulme Trust, Marie Skłodowska-Curie Actions, German Research Foundation (DFG), European Research Council, and Wellcome Trust.

ENDS

PHOTO CAPTION – please credit Konstantin Nechaev/Alamy Stock Photo

•    Tropical Fruit Fly Drosophila Diptera

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Notes to editor:

•    The University of Birmingham is ranked amongst the world’s top 100 institutions. Its work brings people from across the world to Birmingham, including researchers, teachers and more than 8,000 international students from over 150 countries.
•    ‘Mating proximity blinds threat perception’ - Laurie Cazalé-Debat, Lisa Scheunemann, Megan Day, Tania Fernandez-d.V. Alquicira, Anna Dimtsi, Youchong Zhang, Lauren A Blackburn, Charles Ballardini, Katie Greenin-Whitehead, Eric Reynolds, Andrew C Lin, David Owald, and Carolina Rezaval is published in Nature.
•    Participating institutions: University of Birmingham, UK; Freie Universität Berlin, Germany; University of Sheffield, UK; and Charité - Universitätsmedizin Berlin, Germany.