image: Figure 2. One of my targeted combinations. Capmatinib – standard everyday use. All other medications - reverse dose application -are given on day 1 only. The number of tablets on day1 are shown.
Credit: 2024 Blagosklonny et al.
BUFFALO, NY- August 6, 2024 – On July 28, 2024, Mikhail V. Blagosklonny M.D., Ph.D., from Roswell Park Comprehensive Cancer Center published a new editorial in Volume 16, Issue 14 of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science), entitled, “Targeted cancer therapy: the initial high concentration may slow down the selection for resistance.”
“Unfortunately, any targeted therapy is, always, started with low levels of the drug in the organism, selecting for drug resistance. One should propose that initial drug levels must be maximized, and durations may be minimized, ideally, as portions of preemptive combination of targeted drugs.”
Read the full paper: DOI: https://doi.org/10.18632/aging.206046
Corresponding Author: Mikhail V. Blagosklonny - Blagosklonny@oncotarget.com, Blagosklonny@rapalogs.com
Keywords: aging, lung cancer, resistance, brain metastases, METex14, capmatinib, rapamycin
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About Aging-US:
The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population.
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Journal
Aging-US
Method of Research
Commentary/editorial
Subject of Research
Not applicable
Article Title
Targeted cancer therapy: the initial high concentration may slow down the selection for resistance
Article Publication Date
28-Jul-2024
COI Statement
The author declares no conflicts of interest related to this study.