Anti-Baldwin Catalysis Diagram (IMAGE)

DOE/SLAC National Accelerator Laboratory

Anti-Baldwin Catalysis Diagram

Caption

This diagram illustrates the two-step process by which the protein Lsd19 catalyzes the formation of the natural antibiotic lasalocid from its precursor, a chemical called bisepoxy-prelasalocid A, first enabling the formation of five-membered rings, then pushing the reaction one more unexpected step to form six-membered rings (one is highlighted in red in the bottom reaction).

Credit

Image by Kinya Hotta

Usage Restrictions

None

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.