Stat3 as Oncogene (IMAGE)
Caption
When EGFR -- a cell-surface receptor --mutates in glioblastoma, the Stat3 protein becomes oncogenic and promotes tumor growth. The image on the left shows EGFR-mutated cancerous tissue in which Stat3 is active and thus advancing tumor activity. The right-hand image shows the same tissue without Stat3 activity, resulting in a healthier sample.
Credit
Harvard Medical School
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