Stat3 as Tumor Suppressor (IMAGE)
Caption
In other subtypes of glioblastomas, Stat3 functions as a tumor suppressor gene. In the tissue samples above, the cancer has lost the tumor-suppressor PTEN, leaving that function almost entirely up to Stat3. In the left-hand image, an active Stat3 holds the cancer at bay. But when Stat3 is lost, as shown in the image on the right, the tumor grows.
Credit
Harvard Medical School
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