During muscle formation, mono-nucleated cells (myoblasts, blue) and their surrounding matrix (orange, ECM) are initially disordered (left). (IMAGE)
Caption
During muscle formation, mono-nucleated cells (myoblasts, blue) and their surrounding matrix (orange, ECM) are initially disordered (left). As they self-organize and align (middle), their cooperative movement remodels the matrix and forms topological defects (red dot). In these areas, mechanical compressive stress (blue glow) intensifies, creating a high-stress hotspot that serves as a fusion hub – directing the myoblasts to fuse into mature, multi-nucleated muscle fibers (myotubes) at the defect site (right).
Credit
Sushil Dubey
Usage Restrictions
Image can only be used in context of this publication.
License
Original content