ISM9546 shows rapid onset of action and robust disease-activity reduction in acute colitis model (IMAGE)

InSilico Medicine

ISM9546 shows rapid onset of action and robust disease-activity reduction in acute colitis model

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In an animal model of acute colitis, ISM9546 demonstrated a significant reduction in disease activity, as measured by the Disease Activity Index (DAI), was observed within just a few days of treatment initiation and was sustained throughout the study period. Compared with a reference VAV1 degrader, ISM9546 exhibited superior disease control, resulting in significantly lower cumulative DAI scores. Histopathological analysis further showed substantial reductions in inflammatory cell infiltration and intestinal tissue injury, with histopathology scores improved by approximately 60%. Collectively, these findings support the further advancement of this ISM9546 for the treatment of IBD.

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Insilico Medicine

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