靶向KRAS联合CTLA-4阻断重塑胃癌免疫抑制微环境的机制示意图 (IMAGE)

Science China Press

靶向KRAS联合CTLA-4阻断重塑胃癌免疫抑制微环境的机制示意图

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KRAS突变驱动TGF-β依赖、Treg主导的免疫抑制微环境；KRASG12D抑制剂联合CTLA-4阻断可抑制TGF-β信号、削弱Treg功能、恢复有效的抗肿瘤免疫。

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