Proposed mechanism of combined KRAS inhibition and CTLA-4 blockade in KRAS-mutant gastric adenocarcinoma (IMAGE)

Science China Press

Proposed mechanism of combined KRAS inhibition and CTLA-4 blockade in KRAS-mutant gastric adenocarcinoma

Caption

KRAS mutation drives a TGF-beta-dependent, Treg-dominant immunosuppressive microenvironment. Combination of the KRASG12D inhibitor with CTLA-4 blockade suppresses TGF-beta signaling, impairs regulatory T cell function and restores effective antitumor immunity.

Credit

©Science China Press

Usage Restrictions

Use with credit.

License

Original content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.