Functional plasticity of three differentiated NPC states: edNPCs reshaping TIME, tdNPCs reprogramming cellular metabolism, and ldNPCs overactivating the cell cycle. (IMAGE)
Caption
(A) Trajectory analysis of NPCs derived from NECC. NPC subclusters are labeled by colors. Shades from deep to light blue demonstrate the trajectory of cell differentiation and development: the darkest blue signifies an early differentiation stage, while the lightest blue represents a late differentiation stage. The arows indicate the differentiation and development trajectories of NPCs. (B) Dynamic expression of ENTPD2, IFITM3, FAM162A, PFKFB3, CDKN3, and MKI67 during the NPCs transitions based on pseudotime analysis. The color keys ranging from gray to red indicate relative expression levels from low to high. (C) Differentially expressed genes along the pseudo-time line were clustered hierarchically into three profiles (color key from blue to red). Representative gene functions and pathways are shown. (D) A schematic diagram showing the malignant progression of NPCs. Abbreviations: NPCs, neuronal progenitor cells; edNPCs, early differentiated neuronal progenitor cells; tdNPCs, transitional neuronal progenitor cells; ldNPCs, late differentiated neuronal progenitor cells; TIME, tumor immune microenvironment; NECC, neuroendocrine carcinoma of the cervix.
Credit
Qinqin Liu, Xinyu Qu, Shuqi Li, Yan Ding, Tingting Ren, Qi'an Jiang, Jingxin Ding, Keqin Hua, Junjun Qiu
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License
CC BY-NC-ND