Sophie Pénisson, Ph.D. (IMAGE)
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A study led by City of Hope and TGen provides a systematic comparison of mutation burdens in organs from both healthy individuals and those with cancers, showing that cancer cells carry approximately four times as many DNA mutations as normal cells. “Instead of most extra mutations being caused only by cancer-driving genes or rare DNA damage, the findings suggest that some people accumulate mutations at a higher mutation rate in their tissues,” said first author Sophie Pénisson, Ph.D., associate professor in TGen’s Early Detection and Prevention Division.
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TGen, part of City of Hope
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