Visual abstract (IMAGE)

First Hospital of Jilin University

Visual abstract

Caption

Schematic overview of the obtained results. Bile cfDNA from patients with biliary strictures obtained at the first ERCP was analysed by ULP-WGS and NGS of 52 targeted genes (Bilemut assay). ULP-WGS enables early malignancy detection with high specificity and tumour-origin discrimination through TF and CNA profile. Integration of TF with the targeted TMB identifies a subgroup of patients with poorer prognosis. Figure created using BioRender. com, CCA, cholangiocarcinoma; cfDNA, cell-free DNA; ERCP, endoscopic retrograde cholangiopancreatography; NGS, next-generation sequencing; PDAC, pancreatic ductal adenocarcinoma; ULP-WGS, ultra-low-pass whole-genome sequencing.

Credit

By Carla Rojo, María Rullan, Miguel Sogbe, et al.

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License

CC BY-NC

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