CNAs in patients with bile positive TF. (IMAGE)
Caption
(A) Tumour type (CCA or PDAC; shown in greyscale), TF (%) estimated by ichorCNA and percentage of the autosomal genome affected by CNAs (losses in blue, gains in orange and no change in white) in the 42 patients with detectable bile TF. Each column represents one patient, ordered from highest to lowest ichorCNA-estimated TF. (B) The heatmap shows the distribution of large CNAs across chromosome arms (rows, from 1p to 22q and X) in patients from (A). Blue indicates loss, orange indicates gain, purple indicates both loss and gain within the same arm, and grey indicates no detected alteration. For each arm, the percentage of patients altered is shown on the side. (C) The histogram shows, for each arm, the proportion of patients with losses (blue), gains (orange) or both (purple). The accompanying pie chart summarises the overall proportion of altered arms accounted for by losses, gains and combined losses and gains across the cohort. CCA, cholangiocarcinoma; CNA, copy-number alteration; PDAC, pancreatic ductal adenocarcinoma; TF, tumour fraction; ULP-WGS, ultra-low-pass whole-genome sequencing.
Credit
By Carla Rojo, María Rullan, Miguel Sogbe, et al.
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Credit must be given to the creator. Only noncommercial uses of the work are permitted.
License
CC BY-NC