(IMAGE)
Caption
(a) Heatmap of the top 10 differentially expressed metabolites. The left sidebar shows pathway classifications, and the top sidebar indicates sample groups (orange = patients with BCD; blue = controls). Notable elevation of pentose phosphate pathway metabolites and depletion of branched-chain amino acids are observed in patients with BCD. (b) ROC curves showing diagnostic performance for AMP (AUC = 0.877, 95% CI: 0.806–0.948), TG (34:1) (AUC = 0.860, 95% CI: 0.784–0.936), sedoheptulose 7-phosphate (AUC = 0.860, 95% CI: 0.844–0.929), and their combination (AUC = 0.957, 95% CI: 0.922–0.993). The dashed diagonal line represents random classification. (c) Bootstrap validation of the combined biomarker panel across 2000 iterations, demonstrating robust performance (AUC = 0.92–0.99, CV = 1.86%)
Credit
Yingke Zhao
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License
CC BY-NC