Figure 5. Cell viability curves for cervical cancer cell lines and control cell lines treated with ADCs. (IMAGE)
Caption
Cell viability curves for cervical cancer cell lines and control cell lines treated with ADCs. The (scFv)-SNAP fusion proteins were conjugated to BG-modified auristatin F, a tubulin inhibitor, to form ADCs. The ADCs were tested in vitro on cervical cancer cell lines and the control cell lines. The cell viability curves are stratified by cell line origin. Panel A shows the cell viability curves generated by treatment of the endocervical cell line HeLa with the MSLN-, LIV-1, and TROP-2-targeting ADCs. Panels B and C show the ectocervical cell lines SiHa and CaSki, respectively. Panel D shows the metastasis origin ME180 cell line, and the control cell lines are shown in panels E-H.
Credit
© Stefan Barth, et al. 2026.
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