Prediction of progression stages and developmental trajectories across CytAssist_1 to CytAssist_8 prostate cancer (PCa) tissue sections. (IMAGE)

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Prediction of progression stages and developmental trajectories across CytAssist_1 to CytAssist_8 prostate cancer (PCa) tissue sections.

Caption

(A) Developmental progression was reconstructed using DPT analysis. Diffusion maps of spatially resolved spots for each sample are presented, displaying coordinates specific to varying GE clusters (left panel) and corresponding dpt_pseudotime values (right panel). (B) The quantitative distribution of dpt_pseudotime values within GE clusters for each sample is visualized as violin plots. (C) Developmental trajectories of GE clusters for each sample are visualized using PAGA graphs, displaying individual spatial spots (left panel) and GE clusters (right panel). (D) The CNV score (left panel) and dpt_pseudotime values (right panel) were integrated into the PAGA graph to illustrate developmental dynamics within each GE cluster.

Credit

Yongjun Quan, Mingdong Wang, Fan Zou, Hong Zhang, Yishan Zhang, Yongchen Jin, Hao Ping

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License

CC BY-NC-ND

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