CAR3 protein found to promote collagen mineralization and strengthen bone formation (IMAGE)
Caption
a) Co-localization of CAR3, COL1A1 and calcium ions during in vitro mineralization of collagen. Scale bar, 100 μm. b) Immunoprecipitation validation of COL1A1-CAR3 interaction in lysates from mineralized BMSCs at late stage. c) HRTEM images PAA mediated intrafibrillar collagen mineralization pretreated with and without recombinant 0.1 mg/mL CAR3 at 6 hours and 12 h, inset: SAED images. Scale bar, 0.5 μm (Left), 100 nm (Right). d) EDS profile of collagen fibrils mineralized with PAA-ACP pretreated with and without recombinant CAR3 (50 μg/mLPAA, 6 h and 12 h). Scale bar, 100 μm
Credit
Dr. Fangfang Song and Prof. Yufeng Zhang from Wuhan University Image source link: https://www.nature.com/articles/s41368-026-00443-6
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CC BY-NC-ND