Both CUDC-907 monotherapy and its combination with temozolomide can effectively inhibit the growth of glioblastoma in vivo. (IMAGE)
Caption
(A) Orthotopic xenografts were established by intracranially injecting LN229 cells (luciferase-expressing) into NOD-SCID mice. (B, C) Representative bioluminescence images and quantification of intracranial xenografts derived from LN229-luc cells treated with solvent/drugs. (D) Immunohistochemistry staining images of Ki67 in xenograft tumors in the mouse brains. Scale bars = 50 μm. (E) Representative hematoxylin-and-eosin-stained images of the liver and kidney tissues from mice treated with CUDC-907 or DMSO. Scale bars = 500 μm. (F) Serum levels of AST/ALT and BUN in mice treated with CUDC-907 or DMSO. The data were expressed as mean ± standard deviation. Student’s t-test was performed to analyze significance. ∗P < 0.05, ∗∗P < 0.01, and ∗∗∗P < 0.001.
Credit
Chencheng Fang, Pan Gou, Dandan Zhang, Xuanxuan Wu, Xiao Li, Man Li, Lu Gan, Jinjin Luo, Hongjuan Cui, Man Xu, Ping Liang
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