Physicochemical membrane disruption strategies for direct cytosolic delivery (IMAGE)
Caption
The schematic illustrates four approaches for delivering extracellular macromolecules (e.g., Cas9 RNPs and plasmid DNA) directly across the plasma membrane: electroporation (via electric currents), sonoporation (via ultrasound-activated microbubbles), photothermal poration (via laser-irradiated gold nanoparticles), and mechanoporation (via nanoneedles or hollow nanostraws).
Credit
Maosong Yang, Jiheng Wang, Chang Chen&Yang Liu
Usage Restrictions
Credit must be given to the creator. Only noncommercial uses of the work are permitted.
License
CC BY-NC