(IMAGE)
Caption
Schematic overview of the pathological skin-bone marrow axis driving psoriasis, based on findings from Kumamoto University researchers. The study revealed that inflamed skin produces G-CSF, which travels to the bone marrow to stimulate emergency granulopoiesis and the overproduction of neutrophils. These neutrophils then infiltrate the skin to worsen inflammation. As demonstrated in the research, experimental therapeutic interventions blocking either G-CSF (anti-G-CSF) or neutrophils (anti-Ly6G) successfully disrupt this destructive cycle and cut clinical and histological psoriasis symptoms in half.
Credit
Kosasih T et al.
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Credit must be given to the creator.
License
CC BY