Lipoic acid trisulfide (LASSS) may turn HGF into “Super HGF” (IMAGE)
Caption
HGF is a key activator of muscle stem cells that normally resides in the extracellular matrix, but becomes dysfunctional with age due to nitration. Researchers show that interaction with lipoic acid trisulfide (LASSS) can convert HGF into “Super HGF,” a form with enhanced receptor-binding affinity and resistance to nitration-induced dysfunction. Disulfide bonds may be potential targets for LASSS-mediated remodeling into trisulfide bonds.
Credit
Ryuichi Tatsumi / Kyushu University
Usage Restrictions
Only for media and non-commercial use.
License
Original content