Prime editing in mice (IMAGE)

University of Zurich

Prime editing in mice

Caption

(1) A disease-causing mutation in the SCN1A gene disrupts signal transmission in nerve cells and promotes epileptic seizures. (2) Using prime editing, this mutation is corrected directly in the genetic material of the nerve cells. (3) This improves neural signal transmission, which is associated with a significantly lower frequency of fever-induced seizures in the mouse model.

Credit

Lucas Kissling, University of Zurich

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