Selection of heat shock protein genes that affect the prognosis of glioma patients receiving radiotherapy (IMAGE)
Caption
(A) Flowchart for the selection of heat shock proteins related to poor prognosis in glioma patients who had undergone radiotherapy. (B, C) Gene expression differences between LTS and STS groups in glioma patients who had received radiotherapy were analyzed in the TCGA (B) and CGGA (C) databases. (D) Differentially expressed genes from the TCGA and CGGA databases were intersected, and HSP genes with differential expression were extracted. (E, F) Heatmap analysis of the expression of differentially expressed HSPs in the TCGA (E) and CGGA (F) databases. (G) Univariate Cox analysis of the hazard ratio of HSP genes on the survival of patients who had undergone radiotherapy. (H) qPCR analysis of HSP90B1 mRNA expression levels in normal brain tissues (n = 4), low-grade gliomas (n = 8), and high-grade gliomas (n = 15). (I, J) Immunohistochemical analysis of HSP90B1 protein expression levels in normal brain tissues (n = 14), low-grade gliomas (n = 19), and high-grade gliomas (n = 59). (K) Assessment of HSP90B1 expression and its link to prognosis in glioma patients (left) who received radiotherapy and even in glioblastoma patients (right) who received radiotherapy from the TCGA database. (L) HSP90B1 expression levels were evaluated in relation to patient prognosis for glioma cases treated with radiotherapy based on data from the CGGA database.
Credit
Jiacheng Xu, Yuduo Guo, Jingjing Yang, Guanjie Shang, Weihai Ning, Deshan Liu, Hongwei Zhang, Yongmei Song
Usage Restrictions
Credit must be given to the creator. Only noncommercial uses of the work are permitted. No derivatives or adaptations of the work are permitted.
License
CC BY-NC-ND